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1 associated gene
No signs/symptoms info
COMMON GENES: 1
1 OMIM reference -
1 associated gene
28 signs/symptoms
Progeria-associated arthropathy
Mandibuloacral dysplasia with type A lipodystrophy

LMNA LMNA


COMMON
GENES
LMNA



Citations in the biomedical literature:


Progeria-associated arthropathy
LMNA
Mandibuloacral dysplasia with type A lipodystrophy



Progeria-associated arthropathy
Mandibuloacral dysplasia with type A lipodystrophy

Classification (Orphanet):
- Rare genetic disease
- Rare systemic or rheumatologic disease
Classification (Orphanet):
- Rare bone disease
- Rare developmental defect during embryogenesis
- Rare endocrine disease
- Rare genetic disease
- Rare skin disease

Classification (ICD10):
(no data available)
Classification (ICD10):
- Congenital malformations, deformations and chromosomal abnormalities -

Epidemiological data:
(no data available)
Epidemiological data:
Class of prevalence: -
Average age onset: -
Average age of death: -
Type of inheritance: autosomal recessive

External references:
No OMIM references
No MeSH references
External references:
1 OMIM reference -
1 MeSH reference: C535705

Mandibuloacral dysplasia with type A lipodystrophy

Very frequent
- Abnormal dentition / dental position / implantation / unerupted / dental ankylosis
- Alopecia
- Clavicle absent / abnormal
- Large fontanelle / delayed fontanelle closure
- Osteolysis / osteoclasia / bone destruction / erosions
- Premature ageing
- Restricted joint mobility / joint stiffness / ankylosis
- Short stature / dwarfism / nanism
- Skin hypoplasia / aplasia / atrophy
- Terminal / third phalangeal bone of fingers hypoplasia
- Wormian bones

Frequent
- Eyebrows anomalies
- Hyperlipidemia / hypercholesterolemia / hypertriglyceridemia
- Insulin resistance
- Proptosis / exophthalmos

Occasional
- Abnormal pigmentary skin changes / skin pigmentation anomalies
- Anomalies of cartilages, joints and periarticular tissue
- Anomalies of eyelids, eyelashes and lacrimal system
- Anomalies of teeth and dentition
- Articular / joint pain / arthralgia
- Autosomal recessive inheritance
- Breast tissue / mammary gland absence / aplasia
- Cataract / lens opacification
- Hearing loss / hypoacusia / deafness
- High vaulted / narrow palate
- Hypotonia
- Muscle anomalies
- Tight skin / lack of elasticity


Progeria-associated arthropathy

(no data available)